10.02.2022

Low extracellular pH activates TRPV1 through the binding of H ions to TRPV1. Describe the properties, including the location, of the site of TRPV1 that allow H ions to bind. Describe the specific location in the cell where ATF3 protein is produced.

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01.02.2022, solved by verified expert
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Answer: 

TRPV1 receptors are found mainly in the nociceptive neurons of the peripheral nervous system,  also in many other tissues, including the central nervous system.

 TRPV1 is involved in the transmission and modulation of pain (nociception), as well as the integration of diverse painful stimuli.

It is activated by heat, protons, proinflammatory cytokines, and associated with pain and inflammation.

ATF3 proteins are localized in the nucleus.Proinflammatory cytokines, glucose, and palmitate all cause ATF3 to be produced in ß cells.

The NF-B and JNK/stress-activated protein kinase (SAPK) signalling pathways, two stress-induced pathways involved in diabetes, are both involved in ATF3 activation.

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Need this store of protein: 

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