In actuality, the DNA sequence of the human genome is NOT random. Some sequences, including some very large sequences, are repeated many times throughout the human genome. Write two ideas you have for how this fact complicates the use of CRISPR gene-editing technology in humans.

repeated DNA sequences decrease the target specificity of the CRISPR-Cas system, and may lead to off-target effects  

Explanation:

The CRISPR-Cas system is a versatile and powerful tool for gene editing. This gene-editing tool consists of a single guide RNA (sgRNA) that guides the Cas endonuclease protein to the appropriate genomic locus, where Cas generate a double-strand break in the DNA and thus induces DNA repair either by Non-homologous end joining (NHEJ) or Homologous Recombination (HR) repair pathways. The sgRNA consists of a 17-20 nucleotide sequence which is complementary to the target DNA, this sequence is called crispr RNA (crRNA). The existence of repeated DNA sequences hampers the specificity of the CRISPR-Cas tool because a particular sgRNA is able to guide Cas9 to different genomic loci that have the same (repeated) nucleotide sequence complementary to the crRNA. In consequence, repeated DNA sequences may lead to undesired off-target effects, i.e., unintended cleavage (and therefore unintended mutations) at untargeted genomic sites.

The Parker probe.

Explaination:

for six years an artificial fertilizer is used on a apple orchard the orchard is next to a stream which empties in to a slat water bay during the last 5 years researchers have observed an increase in algae in the bay they have also sampled fish populations in the bay each year apex...

Answer:

Effective food supply was most likely an effect on society that resulted from improvements in blood handling during World War I and World War II.

One parrot species that feeds on large seeds nests is in the same tree as a parakeet that feeds on small seeds, they occupy different niches.

The T-chart by categorizing each statement as something that would most likely be relevant to gene flow or genetic drift. Some answers will fit in both columns depending on the situation. is random is a mechanism for evolution is often related to disasters is also called “migration” deals with movement between populations...

Angelica suffers from lupus disease.people with this disease are extremely sensitive to sun light.

Rank the following cities in order of earthquake risk from high risk to low risk:

The nerves and muscles communicated with each other to trigger her reflexive response…

when soaked in dilute sodium chloride solution onion gain mass because of the process of osmosis.

 Explanation: Osmosis is a process when there is movement of water from the region of comparatively higher concentration to the region of lower concentration across in a permeable membrane.

Example with explaination :